NAD Shot: What to Know Before You Get One

What is an NAD Shot?

NAD shots deliver nicotinamide adenine dinucleotide directly into your body through an injection, bypassing the digestive system. 

So, what is NAD exactly?

NAD is a coenzyme that exists in every single cell of the body. It’s involved in energy production, cellular repair, and hundreds of other processes that keep your body functioning. But like many things, your natural NAD levels drop as you get older. And this decline has been associated with low energy, slower recovery, and cellular aging. 

By administering NAD through an injection—either into the muscle or through an IV—the goal is to bypass digestion and allow for direct absorption into the body.

You’ll typically find NAD shots offered at wellness clinics, med spas, and telehealth platforms. They're often marketed for energy, mental clarity, and longevity-related benefits—but what does the evidence actually say? What are the potential benefits and risks?

NAD Shots vs Injections

The terms NAD shot and NAD injection are often used interchangeably—and in many cases, they refer to the same general idea: NAD delivered through a needle.

With that said, subtle differences can exist depending on the provider. NAD shot most commonly refers to a quick intramuscular (IM) injection, similar to a vitamin B12 shot. These injections are typically completed in minutes and deliver NAD into the muscle, where it’s gradually absorbed into the bloodstream.

NAD injection is sometimes used more broadly and may also include intravenous (IV) infusions, which deliver NAD directly into the bloodstream over a longer period—often ranging from one to several hours, depending on the dose and protocol. IV delivery allows for higher doses but requires more time and is generally more expensive.

If you’re comparing options, ask a qualified healthcare provider how the NAD is administered (IM vs. IV), the dose you’re receiving, and how long the session takes. Terminology varies, but these details clarify what you’re actually getting.

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Potential NAD Shot Benefits 

Most often, NAD shots and their benefits, as well as NAD injection benefits, are one and the same. However, the delivery method and dose are what typically vary between these two. Overall, here are what most people expect to achieve through NAD shots or injections:

• Energy support: NAD plays a central role in how your cells produce energy. NAD is thought to support mitochondrial function—the powerhouse of your cells—which could translate to more sustained energy throughout the day.
• Mental clarity: Because NAD supports neurological function and cellular repair, some people report feeling sharper and more focused after treatment. Research in this area is still emerging, and early studies are exploring NAD's relationship to cognitive function, but evidence in humans is limited and not conclusive.
• Support for healthy aging: This is where NAD has generated the most buzz. NAD is linked to sirtuins—proteins associated with longevity and cellular maintenance. Yet, human studies are still catching up to animal research.
• Cellular maintenance support: NAD is involved in enzymatic processes associated with DNA maintenance and normal cellular function.

It’s worth noting that while these benefits are promising, much of the research is preliminary or based on animal models. Individual results vary, and NAD shots are only one piece of any broader treatment plan or health strategy.

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What Are the Possible Side Effects of Nad Shots?

Common side effects may include:

• Nausea
• Flushing or warmth
• Lightheadedness or dizziness
• Discomfort at the injection site (such as redness, soreness, or mild bruising)
• Chest tightness or pressure
• Fatigue

Other side effects may also include:

• Headaches
• Muscle cramping
• Digestive discomfort

Most of these side effects are temporary and resolve on their own within a few hours. A licensed healthcare provider experienced with NAD therapy can adjust the infusion rate or dosage to minimize any discomfort. If you have underlying health conditions or are taking medications, it’s important to discuss NAD therapy with your healthcare provider beforehand.

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What to Expect During an NAD Shot

If you’ve never had an NAD shot before, knowing what to expect can make the experience a lot more comfortable and help calm your nerves.

Most providers recommend showing up well-hydrated and having eaten something light. Some clinics may ask you to complete a health questionnaire or have a brief consultation beforehand—especially if it’s your first session.

For a standard intramuscular (IM) NAD shot, the process is quick. A qualified provider will clean the injection site—usually the upper arm or glute—and administer the shot. The whole thing typically takes just a few minutes. You might feel a brief sting or slight pressure.

If you’re getting an IV infusion, expect to be there longer. You’ll be seated or reclined while NAD is delivered directly into your bloodstream through an IV line. These sessions can range from 30 minutes to a few hours depending on the dose. Many people read, work on their phones, or just relax during the infusion. Your provider may also adjust the drip rate based on how you’re feeling.

Some people feel effects right away—warmth, mild nausea, or a sense of relaxation. Others don’t notice much until afterward. If anything feels uncomfortable, let your provider know so they can adjust.

Once you’re done, you’re usually free to go about your day. There’s no major downtime—most people return to normal activities immediately, though you may want to skip intense workouts right after if you’re feeling lightheaded.

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Final Thoughts

The research on NAD is promising but still evolving, and individual results can vary. Managing your expectations and working with a qualified provider can help you get the most out of the experience. 

If you’re considering NAD shots, take the time to ask questions about dosing, delivery method, and realistic outcomes for your specific goals. And as with any wellness treatment, it’s always a good idea to check in with a healthcare provider, especially if you have underlying health conditions or are taking other medications.

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