NAD Supplement: What It Is, Benefits & Risks

What are NAD Supplements?

NAD (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It plays a role in hundreds of metabolic processes, including the conversion of food into energy and the support of DNA repair. 

However, as we age, NAD levels naturally decline. Some research even indicates NAD levels can be 10-80% lower with increasing age. And this is where NAD supplements may provide support.

These supplements typically contain precursors like NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside), which your body converts into NAD. But do these supplements actually deliver? What benefits can they offer? And are there any downsides?

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NAD Supplement Benefits

Research on NAD supplementation is still evolving, but early evidence is promising. Here are some of the most talked-about benefits.

May Support Cellular Energy Production

NAD helps convert the food you eat into ATP—the fuel your mitochondria use to power nearly every function in your body. As NAD levels decline with age, so does mitochondrial function. In fact, mitochondrial dysfunction is associated with various chronic diseases, including neurodegenerative, cardiovascular, and neuromuscular conditions.

While NAD supplementation has not been shown to treat or prevent these diseases, increasing NAD may support cellular energy pathways; yet, the extent of this benefit can vary from person to person. 

At the same time, research indicates that NAD supplementation may reduce perceived fatigue in some individuals, also suggesting improved energy production.

May Contribute to Better Metabolic Health

One study in prediabetic women found that NMN supplementation (a precursor of NAD) improved muscle insulin sensitivity, which is important for blood glucose regulation. While these early results are promising, these findings are limited. Larger, longer-term human trials are needed before NMN can be considered a proven metabolic therapy.

May Benefit Cardiovascular Health

Heart disease remains the leading cause of death worldwide. 

But here’s some good news: Research suggests that NAD-related pathways may support cardiovascular function by improving energy production in heart cells, supporting endothelial function and healthy blood pressure, as well as contributing to a healthy inflammatory response.

May Support Muscle Function and Physical Performance

From mid-age onward, we lose about 1% of our muscle mass each decade. But NAD may play a role in maintaining strength and endurance. Additionally, evidence suggests that lower NAD levels may be detrimental to muscle health. 

Research on older men has even shown improvements in gait speed and grip strength after NMN supplementation. While more research is also needed here, NAD and its precursors may play a role in maintaining muscle function and performance, especially with increasing age.

May Improve Brain Health

NAD may further play a role in maintaining healthy brain cells. Early research explores how NAD-related pathways may interact with cellular processes involved in cognitive aging.

Some studies also link NAD precursors to improved sleep quality, likely due to their effects on cellular energy balance and circadian rhythm regulation. In turn, this could also contribute to better brain health and cognition.

May Support Cellular Health as You Age

Beyond energy production, NAD is essential for enzymes involved in DNA repair. Your cells constantly face damage from environmental stressors, and the mechanisms that fix this damage depend on adequate NAD availability. 

While human clinical trials haven't yet proven that supplementation directly improves DNA repair outcomes, the biological rationale is there. The research simply needs to catch up!

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NAD Supplement Risks and Side Effects

NAD supplements are generally considered well-tolerated, with most individuals reporting no serious adverse events. However, as with any supplement, side effects may occur, such as:

• Mild gastrointestinal discomfort (nausea, bloating, diarrhea)
• Skin flushing or skin warmth
• Headaches or dizziness
• Fatigue or sleep issues

Additionally, most research studies on NAD have only lasted weeks or months, so the long-term effects of NAD supplementation remain unknown. And because these supplements are regulated differently than prescription drugs, and are not subject to the same premarket approval process, quality and potency can vary between brands. 

If you’re taking any medications or have underlying health conditions, talk to your healthcare provider before starting NAD supplementation.

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Final Thoughts

NAD supplements have generated a lot of interest and hype—and for a good reason. The scientific evidence supporting NAD’s role in energy production, cellular repair, and cellular health as you age is exciting. However, individual responses may vary, and it’s always important to discuss what’s right for you and your specific health situation with a licensed healthcare provider.

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