Rybelsus® Weight Loss: How It Works, Results & Risks

What is Rybelsus®?

Rybelsus®, an oral form of semaglutide, often comes up when discussing other GLP-1 medications. While it’s FDA-approved, specifically for type 2 diabetes, you may wonder if it can support your weight management goals. 

But first, what is semaglutide anyway? And how exactly does the oral form, Rybelsus®, work?

Semaglutide falls under a class of medications called GLP-1 receptor agonists. As a prescription drug, it’s used under medical supervision, primarily for blood sugar management. 

Rybelsus® is taken orally, offering a convenient alternative to traditional injectable GLP-1 therapies. However, it’s worth noting that only a qualified healthcare professional can determine if semaglutide is right for you and your situation.

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How Does Rybelsus® Work?

Rybelsus® contains semaglutide. This and other GLP-1 receptor agonists mimic the hormone GLP-1 (glucagon-like peptide-1), which is released after eating and can help regulate appetite, digestion, and blood sugar levels. 

In this way, Rybelsus® contributes to:

• Slower stomach emptying
• Reduced appetite and fewer food cravings
• Increased insulin secretion (when blood sugar is elevated)

Since it’s taken orally, Rybelsus® is absorbed through the stomach lining. This means it’s best taken first thing in the morning on an empty stomach, with a bit of water. Waiting about 30 minutes before you eat or drink anything also ensures it’s properly absorbed. 

So, what kind of benefits are linked to this medication?

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Rybelsus® Benefits

Rybelsus® is FDA-approved for type 2 diabetes, meaning its primary benefit revolves around blood sugar management. So, here’s what is most commonly experienced when taking this oral form of semaglutide.

Supports Blood Sugar Management

When used as prescribed, semaglutide helps regulate insulin and blood sugar. For instance, after a meal, it helps improve the body’s insulin response, which keeps blood sugar levels within healthy ranges.

May Reduce A1C Levels

A1C levels indicate how much sugar is attached to the hemoglobin in your red blood cells, and higher levels suggest higher blood sugar levels over time. Thus, many individuals with uncontrolled diabetes tend to have higher A1C levels.

However, studies show that semaglutide can help improve A1C levels, indicating better blood sugar control.

May Reduce Appetite

Because it slows stomach emptying, many report feeling fuller for longer when taking Rybelsus®. In turn, this could lead to fewer cravings. Not everyone experiences appetite or weight changes, and any weight loss is not guaranteed.

Offers a Convenient Option

Injections can be cumbersome, requiring a bit more time, proper storage, and proper technique. Yet, taking semaglutide orally makes long-term therapy more accessible and convenient.

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Rybelsus® and Weight Changes

Because Rybelsus® (oral semaglutide) slows stomach emptying and may reduce appetite, some individuals taking it for type 2 diabetes notice weight changes over time.

A few important points to keep in mind about Rybelsus® weight loss results:

• Rybelsus® is not FDA-approved as a weight loss drug.
• Any weight changes are considered a side effect while using Rybelsus® for blood sugar management.
• Not everyone loses weight; some people may see little change or even gain weight.

If weight loss is your primary concern, talk to your healthcare provider about your options, including medications that are specifically approved for chronic weight management.

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Rybelsus® Side Effects

Like other GLP-1 medications, side effects can happen when taking Rybelsus®. While not everyone experiences them, it’s always good to know what could occur.

Side effects may include:

• Nausea
• Stomach upset
• Decreased appetite
• Diarrhea
• Vomiting
• Constipation
• Heartburn
• Bloating
• Fatigue

Serious side effects and important warnings

Serious side effects are less common but can occur. If you experience any signs of pancreatitis, such as severe abdominal pain, a rash, swelling, difficulty breathing, or intense stomach pain, it’s essential to seek immediate medical attention.

Rybelsus® also has a boxed warning about the risk of thyroid C-cell tumors seen in animal studies. Because of this, it should not be used by people with:

• A personal or family history of medullary thyroid carcinoma (MTC), or
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Tell your healthcare provider right away if you notice a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Additionally, it’s not recommended during pregnancy. Always discuss your plans with a licensed healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. 

This is not a complete list of side effects or risks. Talk with your healthcare provider and review the full Prescribing Information and Medication Guide for more details.

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Final Thoughts

When it comes down to it, Rybelsus® is approved for adults with type 2 diabetes to help manage blood sugar. It’s not suitable for every person, and it’s not approved as a weight loss drug. As such, discussing your options with your healthcare provider can help you determine if it’s right for you and your situation.

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