Liraglutide vs Semaglutide: Key Differences & Risks

How Does Semaglutide Differ From Liraglutide?

Semaglutide and liraglutide are both GLP-1 receptor agonists. But this doesn’t mean they’re identical. While they may yield similar outcomes, they differ in dosing schedules, formulations, potencies, and tolerability.

Due to these differences, it’s always important to discuss what’s right for you with your licensed healthcare provider. They know you and your health situation best and can offer personalized guidance.

For more info about the exact differences between liraglutide vs semaglutide, keep reading below.

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What is Semaglutide?

Semaglutide is best known under the three brand names: Ozempic®, Wegovy®, and Rybelsus®. It’s available in two prescription forms, as either an injectable or oral pill. 

With the injected format (Ozempic® or Wegovy®), it’s usually taken once a week. Meanwhile, the oral pill (Rybelsus®) is taken once daily, with a bit of water. After taking the pill form, it’s advised to wait at least 30 minutes before eating or drinking.

Like other GLP-1 receptor agonists, semaglutide stimulates the GLP-1 receptor, which plays a role in blood sugar regulation and appetite signaling.

Here’s a quick breakdown of what each brand name has been FDA-approved for:

• Ozempic®: Approved for type 2 diabetes to improve glycemic control and to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular diseases.
• Wegovy®: Approved for chronic weight management, as an adjunct to a reduced-calorie diet and increased physical activity, in adults and certain adolescents with obesity (BMI  ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with at least one weight-related condition (such as hypertension, type 2 diabetes, or dyslipidemia), as described in the FDA-approved prescribing information.
• Rybelsus®: Approved for adults with type 2 diabetes to improve glycemic control.

All forms of semaglutide must be prescribed by a licensed healthcare provider, who can determine whether it’s appropriate based on your current health status and medical history.

What is Liraglutide?

Liraglutide (sold under the brand names Victoza® and Saxenda®) is another GLP-1 receptor agonist, but it differs from semaglutide in a few ways, including:

• It’s taken once daily; there is no weekly option.
• It has a shorter duration of action, which is why it must be injected daily.
• It’s only available as an injectable.

Victoza® is FDA-approved for adults and pediatric patients ages 10 or over with type 2 diabetes. Saxenda®, on the other hand, is FDA-approved for chronic weight management for adults meeting specific BMI criteria and some adolescents.

In particular, liraglutide may offer some individuals more flexibility with daily dosing. However, this can vary from person to person. It may also come down to what you, individually, tolerate better.

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Which is Safer, Liraglutide or Semaglutide?

At the end of the day, liraglutide and semaglutide both come with risks, contraindications, and side effects. Which one is safer or more appropriate depends on the individual, including your medical history, other medications, and how you respond to treatment.

Semaglutide Side Effects

Semaglutide’s most common side effects involve gastrointestinal symptoms, especially when first starting this medication. These may include:

• Nausea
• Diarrhea
• Vomiting
• Constipation
• Stomach discomfort
• Decreased appetite

On the other hand, less common side effects may include pancreatitis, kidney issues, or gallbladder problems. If any abnormal or severe symptoms arise, it’s essential to seek out immediate medical attention.

Liraglutide Side Effects

While side effects vary from person to person, liraglutide has similar side effects to semaglutide, such as:

• Nausea
• Constipation
• Vomiting
• Abdominal discomfort
• Diarrhea
• Reduced appetite

Severe, but less common, side effects are also similar to semaglutide. Ultimately, your doctor will determine which is the safer option for you.

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Liraglutide vs Semaglutide: A Side-By-Side Comparison

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Final Thoughts

While either liraglutide or semaglutide can be an effective option, the right choice depends on your health history and your doctor’s recommendations. They have similar mechanisms of action, but slight differences may make one more suitable for you and your situation.

As always, never stop or start any medication without proper guidance from a licensed healthcare practitioner.

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