Gut Trouble on GLP-1s? How to Support Your Digestion

Why GLP-1s May Upset Your Stomach

GLP-1 medications work by slowing down the rate at which your stomach empties (called gastric emptying) and enhancing feelings of fullness. While this can help with appetite and blood sugar regulation, it may also disrupt the natural rhythm of your digestive tract.

Common GI Side Effects:

• Constipation: Slower movement of food may reduce bowel regularity.
  
• Nausea or Bloating: Delayed stomach emptying may lead to a feeling of fullness or discomfort.
  
• Diarrhea or Loose Stools: Fermentation of undigested food in the gut may cause irregularity or urgency.
  
  

These symptoms are most likely to occur during dose escalation, but they can persist without nutritional and hydration support.

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What the Research Says

• A 2024 review in Obesity Pillars found that gastrointestinal side effects were the most frequently reported adverse effects among GLP-1 users, with constipation affecting up to 24% and diarrhea up to 20%.
  
• Many of these effects were dose-dependent and more common in the early weeks of therapy.
  
• Symptoms were often improved by dietary modifications such as increasing fiber and using targeted supplementation strategies.
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How to Support Your Gut During Treatment

You don’t need to wait for symptoms to resolve on their own. Proactive steps can make a big difference in how your gut feels while on GLP-1 therapy.

1. Hydrate Strategically

Water alone isn’t always enough. Include electrolytes to help your body absorb fluids and support regularity.

2. Prioritize Soluble Fiber

Foods like oats, chia seeds, and bananas offer gentle, fermentable fiber that may support both regularity and microbial balance.

3. Limit Fermentable Sugars and Alcohols

Artificial sweeteners and sugar alcohols (like erythritol or sorbitol) may worsen bloating and loose stools. Check labels on sugar-free products.

4. Add Digestive Support

Probiotics and enzymes may help break down food and restore microbial balance, especially when your diet is reduced.

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Why Gainful Gut Health Boost Is a Smart Addition

Gainful Gut Health Boost is formulated for individuals looking to support digestive comfort during dietary transitions, including those taking GLP-1 medications.

What Sets It Apart:

• Clinically backed probiotics may support microbial balance
  
• Digestive enzymes that may assist in nutrient breakdown
  
• No added sugar or fillers, making it suitable for sensitive stomachs
  
• Gainful’s Gut Health Performance Boost is available in customizable options to align with your personal preferences and dietary routines.
  
  

Because food intake often decreases on GLP-1s, ensuring optimal digestion of the food you do eat becomes even more important.

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When to Talk to a Provider

If your GI symptoms are persistent, worsening, or interfering with your quality of life, don’t wait. A licensed healthcare provider may determine whether adjustments to your treatment plan are appropriate, based on your symptoms and medical history.

Eden connects you with independent, licensed providers who can evaluate your experience and help you manage side effects for a smoother journey.

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Conclusion: You Don’t Have to Live With Gut Discomfort

Digestive side effects are common during GLP-1 treatment, but they don’t have to derail your progress. From dietary tweaks to supplement support, small changes can make a big difference in your daily comfort.

Gainful Gut Health Performance Boost offers targeted, gentle digestive support during appetite changes and calorie reduction, without added discomfort. And with Eden, you have access to professional guidance every step of the way.

Eden does not manufacture Gainful products. Please consult your provider prior to making any changes. 

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Explore More from This Series:

• The 4 Most Common Side Effects of GLP-1s and How to Manage Them
  
• Why You're Feeling Sluggish: The Hidden Dehydration Effect of GLP-1s
  
• Muscle Loss on GLP-1s? What You Need to Know
  
• The Nutrition Gap No One Talks About on GLP-1s
  
• What a Balanced GLP-1 Routine Looks Like
  
• Ask a Provider: Do I Really Need Supplements on GLP-1s?
  
  

How to Stick With Your GLP-1 Plan Long Term