Does Semaglutide Make You Tired? Fatigue, Causes & Next Steps

Can Semaglutide Make You Tired?

Most medications come with a list of potential side effects. And semaglutide is no exception. 

FDA-approved for type 2 diabetes and chronic weight management in adults who meet specific BMI criteria, semaglutide is a GLP-1 receptor agonist—a type of medication that mimics the action of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1). 

This hormone helps regulate blood sugar levels, slows digestion, and signals feelings of fullness to the brain. And semaglutide is the active ingredient in several well-known, FDA-approved brand-name medications, including Wegovy®, Ozempic®, and Rybelsus®.

But some users complain of “semaglutide fatigue”—temporary tiredness or a lack of energy, specifically when first starting this medication. So, why is one of the semaglutide side effects tiredness? 

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Semaglutide Side Effects

Common, but often temporary side effects of semaglutide include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach discomfort
• Headaches
• Fatigue or tiredness
• Dizziness

For many people, these side effects are mild and tend to improve over time as the body adjusts to the medication. 

More serious side effects may involve pancreatitis (inflammation of the pancreas), gallbladder issues, and kidney problems. 

Additionally, semaglutide is not recommended for people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. If you develop severe or persistent symptoms at any time, contact your healthcare provider immediately.

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Causes of Semaglutide Side Effects: Fatigue

Because semaglutide affects how your body processes food and regulates energy, it’s not uncommon for some people to notice changes in how they feel—including temporary tiredness. If you’re noticing semaglutide fatigue and wondering, “Does semaglutide cause fatigue?” you’re not alone.

This fatigue may also happen due to:

• A reduced calorie intake
• Blood sugar changes
• Gastrointestinal symptoms (which can lead to dehydration and fatigue)
• Metabolic adjustments

For most people, however, this tiredness is temporary and improves as the body adjusts.

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How Long Does Fatigue Last on Semaglutide?

Fatigue is most common during the first few weeks of treatment, especially during dose increases. For many people, this tiredness improves within a few weeks to a couple of months. 

With that said, however, timelines vary from person to person.

If your fatigue doesn’t improve after several weeks or gets worse, reach out to your licensed healthcare provider. They can evaluate other factors that may contribute to low energy—such as low iron, thyroid concerns, vitamin deficiencies, anemia, or sleep issues—and help determine whether your treatment plan needs adjustments.

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How To Increase Your Energy on Semaglutide

Feeling tired doesn’t necessarily mean you have to stop your treatment. Several supportive strategies may help you maintain energy levels while your body adjusts, such as:

• Staying hydrated: Aim for at least 64-80 ounces of water daily. Consider electrolyte drinks if you’ve had episodes of vomiting or diarrhea.
• Eat nutrient-dense, balanced meals: Prioritize lean proteins, complex carbohydrates such as whole grains and vegetables, and healthy fats, which can help provide sustained energy.
• Don’t skip meals: While semaglutide reduces appetite, going too long without eating can leave you feeling drained. If you’re struggling, try having several smaller meals throughout the day.
• Prioritize your sleep: Aim for 7-9 hours of quality sleep each night. Make sure you establish a consistent sleep schedule and create a calming bedtime routine to help your body ease into those restful nights.
• Incorporate light physical activity: It may seem counterintuitive, but gentle movement—like a short walk or light stretching—may help improve energy levels.
• Follow your titration schedule: Gradual dose escalation allows your body to adjust with greater ease.
• Manage any stress: High stress levels can deplete your energy even further. Try incorporating stress-reduction techniques, such as meditation or deep breathing. 

If your fatigue persists or interferes with your daily activities, contact your healthcare provider. They may recommend lab tests to rule out other causes or suggest adjustments to your dosage or treatment plan.

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Final Thoughts

Fatigue with semaglutide is a reported side effect, and it’s often temporary. Thus, it’s important to remain patient, stay consistent with supportive habits, and communicate openly with your healthcare provider. 

Before making any changes to your treatment, always consult with a licensed healthcare provider. They can assess your current treatment and health status to determine the best path forward for you and your health.

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