NMN vs. NR: Comparing NAD+ Precursors

How They Work in the Body

NR (Nicotinamide Riboside)

• Found in trace amounts in milk and certain foods
  
• Converts to NMN, which is then converted into NAD+
  
• used in research on metabolic function and aging
  
• Available in various supplement forms
  
  

NMN (Nicotinamide Mononucleotide)

• One step closer to NAD+ than NR
  
• Naturally present in broccoli, edamame, and avocado
  
• May convert directly into NAD+ in certain tissues, although research is ongoing
  
• Recently allowed for over-the-counter use in the U.S.
  
  

In both cases, the body processes these precursors and uses them in the same NAD+ production pathway.

What the Research Says

So far, NR has more published human studies, particularly on:

• Energy metabolism
  
• Muscle performance
  
• Cardiovascular health markers
  
  

NMN research is newer but growing. Early studies are looking at:

• Insulin sensitivity
  
  
• Cognitive markers in aging
  
  
• Cellular repair processes
  
  

It’s too early to declare a winner—both compounds show potential for supporting NAD+, but neither has been approved to treat or prevent any condition.

How to Choose Between NMN and NR

Here are a few factors to consider when selecting a precursor:

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Many users try both over time or combine one with lifestyle strategies like fasting or NAD+ injections for multi-layered support.

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Where NAD+ Injections Fit In

While NR and NMN are taken orally, NAD+ injections are administered under the skin, bypassing the digestive system. They are only available by prescription and may allow for:

• Personalized dosing
  
• Potentially more direct delivery
  
• Ongoing provider monitoring
  
  

For individuals who haven’t noticed results from oral supplements—or who want more consistent support—this may be worth discussing with a licensed provider.
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Final Thoughts

Both NMN and NR have value as precursors to NAD+. They are widely used by people looking to support their metabolism, energy levels, and recovery routines.

Choosing the right approach depends on your goals, preferences, and how your body responds to them. And if you’re looking for a provider-supervised option, NAD+ injections may be the next step.
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Disclaimer

NAD+ therapies are not FDA-approved and have not been reviewed for safety, effectiveness, or manufacturing quality. NAD+ injections are available only by prescription. Eden does not make, produce, or dispense medications. We connect patients with licensed providers and state-licensed compounding pharmacies. Individual results may vary.

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