NMN vs. NR: Comparing NAD+ Precursors

Carson @ Eden

May 6, 2025

Last Updated:

Energy + Mood

10 min read

Learn the difference between NMN and NR—two popular NAD+ precursors. Compare how each works and what to consider when supporting NAD+ levels.

Key takeaways

NMN and NR are both NAD+ precursors—compounds your body converts into NAD+
They differ slightly in their absorption and metabolism.
NR has more published studies done on humans, while NMN research is still growing.
Both are used in NAD+ supplement routines, though results may vary from individual to individual
Eden connects you with licensed healthcare providers if you’d like to explore NAD+ injections for more direct support. Please note that you must undergo a health assessment and eligibility is not guaranteed.

Supplements are not evaluated by the FDA. This supplement/product is not intended to diagnose, cure, treat, or prevent any disease.

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What Are NAD+ Precursors?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme essential to cellular energy and healthy DNA maintenance. But as we age, NAD+ levels may naturally decline.

That’s where precursors come in.

Precursors are nutrients which your body can convert into NAD+. Two of the most researched are:

NR (nicotinamide riboside)
NMN (nicotinamide mononucleotide)

Both are available as over-the-counter supplements and are being studied for their role in supporting NAD+ levels as part of a wellness routine.

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Important safety information

How They Work in the Body

NR (Nicotinamide Riboside)

Found in trace amounts in milk and certain foods
Converts to NMN, which is then converted into NAD+
used in research on metabolic function and aging
Available in various supplement forms

NMN (Nicotinamide Mononucleotide)

One step closer to NAD+ than NR
Naturally present in broccoli, edamame, and avocado
May convert directly into NAD+ in certain tissues, although research is ongoing
Recently allowed for over-the-counter use in the U.S.

In both cases, the body processes these precursors and uses them in the same NAD+ production pathway.

What the Research Says

So far, NR has more published human studies, particularly on:

Energy metabolism
Muscle performance
Cardiovascular health markers

NMN research is newer but growing. Early studies are looking at:

Insulin sensitivity
Cognitive markers in aging
Cellular repair processes

It’s too early to declare a winner—both compounds show potential for supporting NAD+, but neither has been approved to treat or prevent any condition.

How to Choose Between NMN and NR

Here are a few factors to consider when selecting a precursor:

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Factor	NR	NMN
Research	More studies published conducted on humans	Growing in mice and early trials
Absorption	Documented in humans	Emerging research shows promise
Availability	Widely available	Now increasingly sold in the U.S.
Form	Capsules, powders	Capsules, some powders

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Many users try both over time or combine one with lifestyle strategies like fasting or NAD+ injections for multi-layered support.

Want to explore NAD+ therapy with professional guidance?
Start with a free provider consultation online.
See if you're eligible
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Where NAD+ Injections Fit In

While NR and NMN are taken orally, NAD+ injections are administered under the skin, bypassing the digestive system. They are only available by prescription and may allow for:

Personalized dosing
Potentially more direct delivery
Ongoing provider monitoring

For individuals who haven’t noticed results from oral supplements—or who want more consistent support—this may be worth discussing with a licensed provider.
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Final Thoughts

Both NMN and NR have value as precursors to NAD+. They are widely used by people looking to support their metabolism, energy levels, and recovery routines.

Choosing the right approach depends on your goals, preferences, and how your body responds to them. And if you’re looking for a provider-supervised option, NAD+ injections may be the next step.
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Disclaimer

NAD+ therapies are not FDA-approved and have not been reviewed for safety, effectiveness, or manufacturing quality. NAD+ injections are available only by prescription. Eden does not make, produce, or dispense medications. We connect patients with licensed providers and state-licensed compounding pharmacies. Individual results may vary.

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Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.