NAD+ Facial Cream vs. Vitamin C Serum

Compare NAD+ cream vs Vitamin C serum to find the best fit for your skincare routine. Learn how each supports skin appearance and texture.

Key takeaways
  • NAD+ creams may support hydration and smoother-looking skin, making them ideal for dry or mature skin types.
  • Vitamin C serums may offer antioxidant protection and support a visibly brighter, more even complexion.
  • These products serve different cosmetic purposes and may be used together.
  • Choose products with transparent labeling and clinically studied ingredients.
  • Eden connects patients with licensed healthcare providers who can discuss personalized care options.

Two skincare ingredients have gained popularity for those looking to support a visibly smoother, more radiant complexion: NAD+ facial creams and Vitamin C serums. But how do they compare, and which one may make more sense for your cosmetic routine?

This guide breaks down how each ingredient works, what benefits they may offer, and how to choose based on your preferences and goals.

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What Is NAD+ and Why Is It Used in Skincare?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body and plays a role in energy metabolism. Levels of NAD+ decline with age, and topical products are being developed to support the appearance of skin as it matures.

In facial creams, NAD+ is used to support hydration and skin texture. These are cosmetic effects. NAD+ skincare products are not drugs and do not alter the structure or function of the skin.

Cosmetic Benefits Commonly Marketed for NAD+ Creams

  • Supports skin hydration
  • May reduce the appearance of fine lines
  • Helps maintain a smooth-looking complexion
  • Often formulated with hyaluronic acid or peptides

Note: NAD+ skincare is intended for external cosmetic use only. Claims suggesting therapeutic effects or permanent changes should be treated with caution.

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What Is Vitamin C Serum?

Vitamin C (ascorbic acid) is a potent antioxidant often used in serums to support tone and brightness. It’s popular for morning skincare routines due to its ability to help neutralize free radicals from UV exposure or pollution.

Cosmetic Benefits Often Attributed to Vitamin C Serums

  • May support a visibly brighter skin tone
  • May reduce the look of uneven texture
  • Often combined with stabilizing agents like ferulic acid
  • Easily layers under moisturizers and sunscreen

Vitamin C serums are not intended to treat or cure skin conditions. They are cosmetic products that support the appearance of healthier-looking skin.

Comparing NAD+ and Vitamin C in Skincare

Feature NAD+ Facial Cream Vitamin C Serum
Primary Role Supports hydration and appearance of texture Antioxidant support and tone enhancement
Form Moisturizing cream Lightweight serum
Best For Dry or mature skin types Oily or combination skin types looking to support a more radiant, even-looking tone
Routine Placement Final step before sunscreen or at night First step after cleansing in the morning
Stability Typically stable in cream form Requires stable packaging and formulation

Can You Use NAD+ and Vitamin C Together?

Yes, these products serve different cosmetic purposes and may be layered within the same routine. For example:

Morning Routine:

  1. Cleanser
  2. Vitamin C serum
  3. Moisturizer
  4. SPF

Evening Routine:

  1. Cleanser
  2. Toner (optional)
  3. NAD+ facial cream

This allows for antioxidant support in the morning and hydration-focused care in the evening.

How to Choose a High-Quality NAD+ Cream

Look for products that:

  • Clearly list NAD+ or precursors like NMN or NR
  • Are fragrance-free and suitable for sensitive skin
  • Offer formulation transparency and third-party testing
  • Include supporting ingredients like ceramides or peptides

Be cautious of products that imply therapeutic or medical outcomes.

How to Choose a High-Quality Vitamin C Serum

Vitamin C is highly effective but also unstable. Choose a serum that:

  • Uses L-ascorbic acid or a stabilized derivative
  • Comes in opaque or dark glass packaging
  • Contains supporting ingredients like ferulic acid or Vitamin E
  • Discloses a concentration between 10%–20%

Avoid products that have darkened or have a metallic scent, as this may indicate oxidation.

Which One May Be Right for You?

Here’s a quick comparison to help guide your cosmetic preferences:

Choose NAD+ Cream if:

  • Your skin feels dry or lacks firmness
  • You want to support hydration and a smoother texture
  • You're building a night-time skincare routine

Choose Vitamin C Serum if:

  • You’re looking to support brightness and tone
  • You want antioxidant support in the morning
  • You prefer a lightweight serum that layers well under SPF

Many people choose to incorporate both products, Vitamin C in the morning and NAD+ cream at night.

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How Eden Supports Your Skin and Wellness Goals

Eden may support your goals by helping you explore treatments that align with your preferences for skin appearance, energy, and overall well-being,guided by licensed professionals.

Eden is a digital health platform that connects patients with licensed healthcare providers. These providers can discuss personalized treatment options, including access to advanced skincare and compounded formulations when medically appropriate.

If prescribed, treatments are shipped from state-licensed pharmacies directly to your door. Eden does not manufacture medications or practice medicine, we facilitate access to care and streamline the process of connecting with experienced medical professionals.

Please note that NAD or NAD+ face cream is not reviewed or approved by the FDA for any claims. 

Bottom Line

NAD+ facial creams and Vitamin C serums both offer cosmetic support for the appearance of smoother, more radiant skin. The key is choosing high-quality formulations, applying them consistently, and aligning your routine with your skin’s cosmetic needs.

Ready to explore skincare options tailored to your goals? Eden can connect you with a licensed provider to help you take the next step.

Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.

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Is NAD+ Face Cream right for you?

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