How NAD+ May Support Metabolic Function in Women Ages 35–55

Why NAD+ Matters for Metabolism

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in hundreds of cellular processes, including energy production, mitochondrial activity, and circadian rhythm regulation.

Research suggests NAD+ may influence enzymes such as sirtuins and PARPs associated with aging and cellular stress adaptation.

Levels of NAD+ tend to decline with age, potentially affecting cellular energy and metabolic function.
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NAD+ and Midlife Metabolic Shifts

Between ages 35 and 55, many women may experience:

• Reduced exercise recovery
  
• Increased visceral fat
  
• Energy instability
  
• Blood glucose fluctuations
  
  

These changes may be associated with perimenopausal transitions, oxidative stress, and sleep disturbances—all of which can influence cellular NAD+ levels.

While not approved to treat metabolic or hormonal disorders, NAD+ has been studied for its potential role in supporting mitochondrial and metabolic processes.
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What Low NAD+ May Feel Like

While there is no definitive way to “feel” low NAD+ levels, some individuals, particularly during midlife transitions, report experiencing symptoms that may relate to changes in mitochondrial efficiency and cellular energy metabolism. These may include:

• Persistent low-grade fatigue
• Post-meal energy dips or “crashes”
• Slower recovery from physical or emotional stress
• Feeling simultaneously wired and tired

These sensations are non-specific and may stem from a wide range of biological or lifestyle factors, including hormone fluctuations, stress, sleep quality, and nutritional status. Early research is exploring how NAD+ may play a role in supporting energy production, mitochondrial activity, and the body's ability to adapt to stress. However, more clinical studies are needed to confirm how NAD+ levels correlate with these symptoms in the general population.

If you're experiencing persistent fatigue or other changes in energy, it's important to consult a licensed healthcare provider to explore the underlying causes and develop a personalized care plan.
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How Eden Can Help

Eden connects individuals with licensed healthcare providers who evaluate your unique health profile and wellness goals. If clinically appropriate, your provider may incorporate prescription NAD+ as part of a broader personalized care plan. Eligibility is not guaranteed and depends on the provider’s medical judgment. 

Prescription NAD+ is typically offered as a compounded injectable formulation and is only available after a telehealth consultation and clinical assessment. Providers on the Eden platform may use lab testing, symptom tracking, and health history to determine whether NAD+ may be a helpful addition to your metabolic support strategy.

A typical program may include:

• A virtual consultation with a licensed healthcare provider
• A tailored NAD+ protocol based on your individual needs
• Regular follow-ups to evaluate your progress and adjust your plan

While NAD+ is not approved by the FDA for treating any specific condition, some licensed healthcare providers may consider it as part of an overall wellness approach aimed at supporting mitochondrial function and cellular energy production.

Learn more about prescription NAD+ injections →
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Standard Disclaimer

This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Prescription NAD+ formulations are only available when deemed clinically appropriate by a licensed healthcare provider following a telehealth consultation. Eden does not manufacture, compound, or dispense medications. All prescriptions are filled by independently licensed U.S. pharmacies. Any health decisions should be made in partnership with a qualified medical professional.
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Curious how your body’s energy systems are functioning?
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