Jardiance vs Metformin: How These Medications Compare for Metabolic Health

Curious about the differences between Jardiance and Metformin? Learn how they work and how licensed providers consider these medications when evaluating treatment options for individuals with glucose management needs.

Key takeaways
  • Jardiance and Metformin act through different mechanisms: Metformin works by reducing liver glucose output, while Jardiance increases glucose excretion via the urine.
  • Jardiance is FDA-approved for type-2 diabetes and heart failure. Metformin is approved for type-2 diabetes and may be used to treat other metabolic conditions under licensed healthcare provider supervision.
  • Providers may consider Metformin for individuals with early indicators of glucose dysregulation, while Jardiance may be prescribed for those with type 2 diabetes and existing cardiovascular risk factors.
  • Eden does not currently include Jardiance in its care offerings. Metformin may be included in Eden’s provider-guided MedKits for individuals who meet specific clinical criteria post-assessment by a licensed healthcare provider.

Please note that compounded medications are not reviewed by the FDA for safety, efficacy, or quality.

What Are These Medications?

Metformin is prescribed for type 2 diabetes and works through:

  • Reducing glucose production in the liver
  • Enhancing insulin sensitivity in peripheral tissues
  • Supporting glucose uptake through insulin-independent pathways

Jardiance (empagliflozin), part of a class called SGLT2 inhibitors, works through:

  • Preventing reabsorption of glucose in the kidneys
  • Increasing glucose excretion in the urine
  • It has also been studied for its potential cardiovascular effects in patients with type 2 diabetes and heart failure

Both medications are taken orally and may be considered part of broader metabolic care plans, but they function in very different ways.

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Key Differences: Jardiance vs. Metformin

Feature Metformin Jardiance
FDA-approved for type 2 diabetes Yes Yes
FDA-approved for heart failure No Yes
May be prescribed for metabolic uses by a licensed healthcare provider Yes (e.g., PCOS, prediabetes) Less common
Primary mechanism Reduces liver glucose production Promotes glucose excretion via urine
Risk of hypoglycemia Low Low, slightly higher with insulin
Gastrointestinal side effects Common Rare
Risk of urinary tract infection Low Moderate
Cardiovascular indications Modest Strong (FDA-approved for heart failure)
Reported weight impact in Studies Mild in some individuals Mild to moderate in some studies

What About Weight Loss?

Neither Metformin nor Jardiance is approved for weight loss. Some individuals may report changes in weight while taking these medications, but results vary. A licensed healthcare provider should guide any use outside of FDA-approved indications.

Q: Why might a provider consider Metformin?

A: Metformin is one of the most commonly prescribed medications for type 2 diabetes and may be prescribed by licensed healthcare providers for individuals showing signs of insulin resistance. Some providers may explore it as an option when evaluating care plans for qualifying individuals. Any decision about medication should be made by a licensed provider based on a full clinical evaluation.

Who Might Be a Candidate for Each?

Metformin may be a discussed option by a provider in situations where a patient:

  • Has been diagnosed with insulin resistance, PCOS, or prediabetes
  • Is exploring non-injectable options for glucose regulation
  • Is looking to manage glucose levels


Jardiance may be discussed by a specialist if a patient:

  • Has type 2 diabetes and cardiovascular disease
  • Has not reached glucose targets with other medications
  • Is under the care of a specialist (e.g., cardiologist or endocrinologist)


How Eden Uses Metformin

Eden’s provider-guided MedKits may include Metformin for eligible members post-assessment by a licensed healthcare provider. These kits are prescribed by licensed providers and may include:

  • Gradual titration of Metformin ER 500 mg
  • Nutrient formulations recommended by providers to support digestive tolerance
  • Monthly check-ins to assess tolerability and adherence

Disclaimer

Metformin and Jardiance are FDA-approved for the treatment of type 2 diabetes. Jardiance is also approved for reducing the risk of cardiovascular death in adults with heart failure. Eden does not produce, dispense, or prescribe medications. All prescriptions are written by independent licensed providers and filled by state-licensed pharmacies. A clinical assessment is required to determine eligibility. Individual experiences may vary.

Please note that compounded medications are not reviewed by the FDA for safety, quality, or efficacy.

Curious if Metformin Could Support Your Metabolic Goals?

Wondering if Metformin might be right for you?

Take Eden’s free provider-guided assessment to explore your options for glucose management and metabolic care.

Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.

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