How Low Doses of GLP-1 Work for Weight Loss

Standard GLP-1 Dosing Schedule

GLP-1 medications are started slowly and increased in a stepwise manner:

• Weeks 1–4: 0.25 mg once weekly (acclimation phase)
  
• Weeks 5–8: 0.5 mg once weekly
  
• Weeks 9–12: 1.0 mg once weekly
  
• Weeks 13–16: 1.7 mg once weekly
  
• Week 17 onward: 2.4 mg once weekly (typical maintenance dose)
  
  

This titration plan is designed to reduce side effects and allow your provider to monitor progress before moving to higher doses¹.

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When Lower Doses May Be Effective

While the full therapeutic dose is often required for optimal results, some individuals may experience appetite changes or weight loss benefits at intermediate doses (e.g., 0.5 mg or 1.0 mg). However, clinical studies show that maximum weight loss typically occurs at 2.4 mg weekly, especially when combined with lifestyle adjustments².

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Factors That Influence Dose Adjustments

Your provider may recommend holding at a lower dose or adjusting the schedule based on:

• Persistent nausea or digestive symptoms
  
• Other medications you are taking
  
• Your medical history and personal treatment goals
  
• Your comfort and response to treatment
  
  

Never change your dose without first speaking with your healthcare provider.

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Best Practices for Starting GLP-1 Therapy

To improve your experience during the early phases of treatment:

• Take your injection on the same day each week
  
• Eat small, balanced meals and avoid heavy or greasy foods
  
• Stay hydrated throughout the day
  
• Log any symptoms to discuss at follow-up visits
  
• Stick to your provider's dosing plan and communicate any concerns
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Final Thoughts

Starting GLP-1 medication at a low dose and gradually increasing over time is a proven strategy to reduce side effects and support long-term treatment success. While early benefits may appear at lower doses, sustained results often require reaching the full maintenance dose, under provider supervision.

Eden connects you with licensed providers who offer GLP-1 treatment plans. Your care team monitors progress, manages dosing, and helps you stay on track at every step.

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