Some individuals taking semaglutide may experience digestive changes like diarrhea. Learn how to manage these effects during GLP-1-based care.
Please note that this article is not meant to be medical advice; please consult with a licensed healthcare provider to determine best practices for your health.
Semaglutide is a GLP-1 receptor agonist that may slow gastric emptying and influence appetite and gastrointestinal hormone activity. These mechanisms may contribute to digestive changes in some individuals, including nausea, bloating, or diarrhea.
Potential contributors to digestive symptoms may include:
A 2024 meta-analysis of clinical studies found that approximately 8–10% of individuals reported diarrhea while taking semaglutide, particularly at higher doses. These symptoms were generally mild to moderate and were more frequently observed during the dose titration phase.
In many cases, diarrhea may improve within the first few weeks of treatment. Duration may depend on:
If symptoms persist for more than 1–2 weeks or interfere with daily life, it is important to speak with a licensed healthcare provider.
Staying well-hydrated may help support digestive health and reduce symptom severity. Individuals experiencing fluid loss should aim to replenish electrolytes as needed.
Some dietary modifications may help alleviate symptoms. Consider limiting the following, which may worsen digestive symptoms for some individuals:
Incorporate foods that are gentle on digestion, such as:
Gradually increase fiber intake to avoid worsening symptoms. Sudden increases may irritate the digestive tract.
In some cases, medications like loperamide may be appropriate, but they should only be used under the supervision of a licensed healthcare provider.
If symptoms are persistent or worsen, a licensed healthcare provider can evaluate and, if needed, adjust the treatment plan or investigate other causes.
Eden is a digital health platform which connects individuals to licensed healthcare providers who may prescribe GLP-1 medications when appropriate. Providers connected with via the Eden platform may support patients with:
Medications are prescribed by licensed healthcare providers and filled by state-licensed compounding pharmacies.
Some individuals may experience digestive symptoms such as diarrhea during semaglutide treatment, especially in the early stages. These effects are often manageable through hydration, dietary adjustments, and support from a licensed healthcare provider. Individuals are encouraged to seek medical guidance to optimize their treatment experience.
Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.
Some individuals may experience diarrhea during treatment with semaglutide, particularly in the early stages of dose adjustment.
Digestive symptoms may improve within 1–3 weeks as the body adjusts, though experiences vary.
You should not stop or adjust treatment without first consulting a licensed healthcare provider.
Strategies may include staying hydrated, eating smaller meals, limiting certain trigger foods, and working closely with a licensed healthcare provider during dose changes.
