Understanding Semaglutide and Its Uses
Semaglutide is a GLP-1 receptor agonist that helps manage:
- Type 2 diabetes (Ozempic®, Rybelsus®)
- Obesity and overweight with related health conditions (Wegovy®)
Semaglutide is FDA-approved for type 2 diabetes (Ozempic®, Rybelsus®) and chronic weight management in individuals with obesity or overweight with related conditions (Wegovy®). These medications work through GLP-1 receptor activity and must be prescribed and monitored by a licensed healthcare provider.
Explore GLP-1 medication options with licensed healthcare providers whom you may connect with via Eden’s platform.
Semaglutide Pricing by Product
Brand |
Use |
Route |
Average Monthly Cost |
Ozempic® |
Type 2 Diabetes |
Weekly Injection |
$800–$1,000 |
Wegovy® |
Weight Loss |
Weekly Injection |
$1,300–$1,500 |
Rybelsus® |
Type 2 Diabetes |
Daily Oral Tablet |
$850–$950 |
Prices reflect typical U.S. retail costs without discounts or insurance and may vary by dose.
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Cost Overview by Insurance Type
Insurance Type |
Estimated Monthly Cost |
Notes |
No Insurance |
$900–$1,800 |
Highest out-of-pocket burden |
Private Insurance |
$25–$300 |
Requires prior authorization in most cases |
Medicare Part D |
Varies (Diabetes only) |
Covers Ozempic® or Rybelsus®, not Wegovy® |
Medicaid |
State-dependent |
May require documentation for coverage |
Medicare generally does not cover semaglutide for weight management unless prescribed for type 2 diabetes. Medicaid eligibility and coverage vary by state.
Pricing Factors That Influence Semaglutide Cost
Variable |
Effect on Cost |
Approx. Range Impact |
Dose Strength |
High |
+$200–$500/month |
Insurance Approval |
Highest |
$0–$1,800/month |
Location/Pharmacy Choice |
Moderate |
±20–30% |
Supply Duration (30 vs 90 days) |
Low–Moderate |
5–15% discount for bulk fills |
Medicare and Medicaid Coverage
- Medicare Part D may cover Ozempic® and Rybelsus® for type 2 diabetes only
- Wegovy® is generally not covered by Medicare, which excludes weight-loss medications.
- Medicaid may approve Wegovy® for obesity treatment in some states with prior authorization.
Cost-Saving Strategies
1. Manufacturer Copay Cards
Novo Nordisk may offer savings programs for eligible commercially insured patients:
Program |
Benefit |
Eligibility |
Ozempic® Copay Card |
$25/month (max savings $150) |
Commercial insurance only |
Wegovy® Savings Offer |
Up to $500/month |
Commercial insurance only |
Individuals without commercial insurance may qualify for income-based assistance programs.
2. Compare Pharmacies
- Use price-comparison tools such as GoodRx or SingleCare to view estimated out-of-pocket costs at different pharmacies.
- Ask your local pharmacy whether they offer cash discounts for self-pay options.
- In some cases, independent or mail-order pharmacies may provide lower prices than larger retail chains. Be sure to verify that any pharmacy you choose is licensed and accredited.
3. Discuss Alternatives
- Consider oral options (e.g., Rybelsus®)
- Ask about other GLP-1s or GIP/GLP-1 dual agonists like tirzepatide.
- Explore metabolic combo therapies (e.g., metformin, bupropion, topiramate). Always consult a licensed healthcare provider before considering combination therapies or alternative medications.
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Yearly Cost Estimates and Planning
Time Period |
Cost Estimate |
Strategies for Reduction |
Month 1 |
$196–$296 through Eden’s platform |
Includes access to an initial consultation with a licensed provider, evaluation of eligibility, and ongoing support services coordinated via Eden. |
Month 2+ |
$250–$1,500/month |
Depends on formulation and pharmacy |
Annual Range |
$3,000–$18,000 |
Use copays, discounts, bulk supply |
Some studies suggest that GLP-1 therapy may have long-term health benefits for individuals with diabetes or obesity; consult with a licensed provider to understand what treatment may be appropriate for your health profile. (PubMed, 2019).
Final Thoughts
The average cost of GLP-1 injections varies widely, from $900 to $1,800/month without insurance to under $300/month with coverage or compounding access. Factors such as brand, dosage, and insurance eligibility significantly affect pricing.
For safe, cost-effective access, work with a licensed healthcare provider who may:
- Help you navigate insurance
- Select the appropriate formulation, when eligible
- Refer you to a reliable pharmacy
- Monitor your progress and adjust treatment as needed
Eden connects users with vetted healthcare professionals and supports the treatment journey from start to finish.
Explore your GLP-1 treatment options
This article is for general informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a licensed healthcare provider for medical guidance and speak with your insurance provider to understand your coverage options. Eden does not practice medicine or dispense medications. Eden connects users with licensed healthcare providers who determine treatment eligibility and refer prescriptions to accredited pharmacies.