Semaglutide Constipation: Causes and Relief Strategies

What Causes Semaglutide Constipation?

GLP-1 receptor agonists like semaglutide slow the rate at which the stomach empties, which can affect the digestive process. This slower movement may help regulate blood sugar and appetite, but for some individuals, it may also lead to constipation.

Contributing factors include:

• Lower Fluid Intake – Decreased appetite may lead to reduced water intake and drier stool.
• Reduced Fiber Intake – Nausea or smaller meals may mean less fiber consumed.
• Slower Transit Time – The colon absorbs more water, making stool harder ¹.
• Changes in Routine or Diet – New eating patterns may disrupt bowel regularity ².

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How Common Is Constipation on Semaglutide?

Rates vary depending on dose and product. According to available data:

• In studies of semaglutide for type 2 diabetes, constipation occurred in approximately 3 to 5 percent of participants.
• In weight management studies, some reports indicated constipation rates of up to 24 percent ¹.
• One analysis noted the average duration of semaglutide-related constipation was about 47 days, though experiences vary and many individuals report shorter durations.

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Does Semaglutide Constipation Go Away?

Constipation may improve as the body adjusts to treatment, especially when hydration, fiber intake, and activity levels are maintained.
Speak with a licensed healthcare provider if symptoms are ongoing or interfere with daily life. Medical advice can help determine whether changes to your care plan are appropriate.

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Tips to Support Digestive Health

The following lifestyle strategies may help ease constipation. These approaches are not guaranteed to resolve symptoms but are commonly used to support general digestive wellness:

• Increase Hydration – May help keep stool soft and promote regularity.
• Add Dietary Fiber – Found in whole grains, beans, vegetables, and fruits.
• Move More Often – Physical activity may help stimulate intestinal function.
• Create a Routine – Using the bathroom at consistent times can help regulate bowel movements.
• Include Fermented Foods – Yogurt, kefir, or sauerkraut contain probiotics.
• Herbal Teas and Warm Fluids – May comfort the gut and support movement.

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When to Consider Over-the-Counter Options

Some patients may benefit from short-term use of non-prescription remedies. Always consult a licensed medical provider before using any medication.

These may include:

• Stool softeners
• Osmotic laxatives
• Stimulant laxatives.

Overuse of laxatives can lead to dependency or worsening symptoms. Follow a licensed healthcare provider’s recommendations carefully.

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Final Thoughts

Semaglutide constipation can be uncomfortable, but individuals may find improvement with hydration, fiber, consistent routines, and medical guidance when needed. It is important to monitor symptoms and communicate with a provider to ensure appropriate support.
Eden connects individuals with licensed healthcare providers who can evaluate whether GLP-1 treatment may be appropriate based on personal health goals. If prescribed, medications are dispensed by state-licensed pharmacies. ⁴. 

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Disclaimer

This article is for informational purposes only and does not provide medical or legal advice. Eden does not manufacture or dispense medications and does not provide medical services. Eden connects individuals with independent, licensed providers who evaluate eligibility for treatment based on clinical judgment

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