How GLP-1 Receptor Agonists and Insulin Complement Each Other

How GLP-1 Receptor Agonists and Insulin Work Differently

GLP-1 receptor agonists, such as semaglutide, mimic the hormone GLP-1 and influence glucose regulation by enhancing insulin secretion in response to meals, suppressing glucagon release, slowing gastric emptying, and promoting satiety. In contrast, basal insulin primarily helps manage fasting blood glucose levels. These medications work through distinct mechanisms, and in some clinical settings, healthcare providers may evaluate whether combining them is appropriate for a patient’s individual needs.

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Clinical Research on GLP-1 and Insulin Use

Numerous studies have evaluated the efficacy of combining GLP-1 receptor agonists with insulin:

• Improved HbA1c: Patients on combination therapy often experience significant reductions in HbA1c levels compared to those on insulin alone.
• Weight Benefits: GLP-1 agonists can counteract insulin-induced weight gain, with some patients experiencing weight loss.
• Lower Insulin Requirements: The addition of GLP-1 therapy may reduce the necessary insulin dosage, decreasing the risk of hypoglycemia.
• Fixed-Ratio Combinations: Medications like IDegLira (insulin degludec/liraglutide) and iGlarLixi (insulin glargine/lixisenatide) have shown efficacy in simplifying treatment regimens and improving patient adherence.

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GLP-1 Treatments

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*On a 12-month plan.

Important safety information

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Safety Considerations and Risk Management

• When GLP-1 receptor agonists are used alongside insulin, licensed providers may evaluate potential risks such as hypoglycemia or gastrointestinal side effects. Nausea, vomiting, and diarrhea are commonly reported during GLP-1 therapy and may lessen with time. Regular medical supervision and blood glucose monitoring are important components of care when using prescription medications.
• Eden does not provide medical treatment or manage medication adjustments, but connects patients with licensed providers who make those decisions based on individual needs.

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Dosing and Administration Guidelines

• GLP-1 Receptor Agonists: Typically administered once weekly via subcutaneous injection. Injection sites should be rotated among the abdomen, thigh, or upper arm.
• Insulin: Basal insulin is usually injected once daily. The timing and site should be consistent; doses may need adjustment upon initiating GLP-1 therapy.
• Fixed-Ratio Combinations: Medications like IDegLira and iGlarLixi combine both agents in a single injection, simplifying the regimen.

‍

GLP-1 Treatments

Personalized doctor-led plans

As low as $196/mo*

Get started

*On a 12-month plan.

Important safety information

‍

Monitoring and Lifestyle Considerations

• Blood Glucose Monitoring: Regular checks, either through fingerstick tests or continuous glucose monitors, help in adjusting therapy effectively.
• Diet and Exercise: A balanced diet and regular physical activity enhance the benefits of combination therapy.
• Patient Education: Understanding the signs of hypoglycemia and how to respond is crucial for safety.

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Conclusion

GLP-1 receptor agonists and insulin therapies have different mechanisms and are sometimes used together in diabetes care under provider supervision. Research has explored how this combination may impact glycemic outcomes, weight, and insulin needs in certain clinical settings. However, combination use requires close medical oversight to manage potential risks such as hypoglycemia.

Eden does not offer fixed-ratio combination therapies but connects patients with licensed providers who determine the most appropriate options based on individual health goals and history.

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