Low-Dose Naltrexone (LDN): What It Is—and What It May Support

Learn what low-dose naltrexone is, how some providers use it off-label, and what early research is exploring about its possible role in emotional and behavioral wellness.

Key takeaways
  • Low-dose naltrexone (LDN) is a compounded, off-label formulation of standard naltrexone, typically administered at doses of 1.5 mg to 4.5 mg.
  • Early research and anecdotal reports have raised interest in how LDN may support mood, immune signaling, and appetite awareness.
  • LDN is not FDA-approved for weight loss, emotional eating, or the treatment of any chronic conditions. It must be prescribed by a licensed provider and compounded by a state-licensed pharmacy.

What Is Low-Dose Naltrexone?

Naltrexone was developed initially at much higher doses (typically 50mg) for the treatment of opioid and alcohol dependence. In recent years, a low-dose version—referred to as low-dose naltrexone (LDN)—has emerged in off-label clinical settings. LDN is generally prescribed in doses ranging from 1.5mg to 4.5mg per day and is only available through a prescription compounded by a licensed pharmacy.

Some providers may explore LDN in individualized care plans focused on emotional and behavioral wellness, but its use remains investigational for these purposes.

Is My Custom Weight Loss Kits™ right for you?

Is My Custom Weight Loss Kits™ right for you?

Get started

How Does LDN Work?

Although research is ongoing, proposed mechanisms of action for low-dose naltrexone include:

  • Temporarily blocking opioid receptors, which may lead to a rebound increase in the body’s natural endorphin production
  • Modulating immune system responses, including effects on glial cell activity and inflammatory signaling pathways
  • Potential influence on hunger and satiety regulation in the brain

These proposed mechanisms have prompted clinical interest in LDN as a possible option within behavior-focused wellness strategies.

What Are the Reported Benefits?

LDN is not FDA-approved for uses beyond addiction treatment. However, some early research and patient reports suggest that some individuals experience:

  • Changes in food-related behaviors or emotional triggers, as reported by some individuals*
  • Some users have reported perceived shifts in emotional response during lifestyle changes*
  • Increased awareness of hunger and fullness cues*
  • Observed changes in wellness that may relate to immune activity or neuroinflammatory pathways*

*These observations are anecdotal or based on preliminary studies and should not be interpreted as confirmed medical benefits.

Commonly Paired with Nutrients in Eden’s Everyday+ Kits

In provider-recommended care plans, low-dose naltrexone may be prescribed in conjunction with select nutrients, some of which are included in Eden’s Everyday+ supplement kits.

Formulas may include:

  • Inositol, often used to support mood and insulin sensitivity
  • Acetyl-L-carnitine, often used in wellness settings for its proposed role in cellular energy metabolism
  • Vitamin B6 and B12, to support cellular energy metabolism

These ingredients are evaluated by licensed medical providers for individual use but are not FDA-approved for weight loss or metabolic treatment.

Who Might Explore LDN?

LDN may be a point of discussion for members who:

  • Are tapering off GLP-1 therapies and want continued support for appetite or mood balance
  • Prefer a non-stimulant, low-dose option for managing emotional or behavioral patterns
  • Are looking for a consistent plan to help reinforce habit changes without starting a full-dose medication
  • Want to explore whether LDN may play a role in their broader wellness strategy, under the guidance of a licensed provider

Provider evaluation is necessary to determine whether LDN is an appropriate fit.

Is LDN Safe?

LDN is only available by prescription and must be compounded by a licensed pharmacy. Many individuals generally tolerate it well, but some may experience:

  • Vivid dreams
  • Mild nausea
  • Headaches

Your provider will assess your medical history and goals before including LDN in any care plan.

Disclaimer

Low-dose naltrexone (LDN) is not FDA-approved for appetite regulation, weight management, mood support, or inflammation. It is prescribed off-label by licensed providers and compounded by state-licensed pharmacies. Eden does not manufacture, compound, or dispense medications. Individual experiences may vary, and results are not guaranteed.

Interested in Exploring LDN-Based Care?

If you’re curious about how low-dose naltrexone may fit into your wellness journey, Eden can help you connect with a licensed provider for a personalized consultation.

Start with a quick online assessment to see if you're eligible for a personalized program.

Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.

Frequently asked questions

My Custom Weight Loss Kits™
For weight loss and appetite support
Starting as low as $49/mo*
Get started
Important safety information
Verified Customer
"I had an incredible experience, and the support that Eden provides is 10/10"
Kerstin
Verified Customer
“I had so many questions in the beginning, and both the doctor and customer support were so patient and thorough.”
Lane L.

Is My Custom Weight Loss Kits™ right for you?

Is My Custom Weight Loss Kits™ right for you?

Get started

References