How to Inject GLP-1 Medications Safely: A Step-by-Step Guide

GLP-1 receptor agonists are prescription medications used to support blood sugar regulation and metabolic health in adults with type 2 diabetes or weight-related conditions. These therapies are commonly administered once weekly via subcutaneous injection.

Whether you have just started therapy or want a refresher on best practices, this guide outlines safe and effective injection techniques for GLP-1 medications, including compounded semaglutide as offered through Eden’s licensed providers.

Compounded GLP-1 medications are not reviewed by the FDA and are prescribed off-label under the supervision of a licensed clinician. Always follow your provider’s instructions for dosing, injection, and monitoring.

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What Are GLP-1 Receptor Agonists

GLP-1 receptor agonists mimic the body’s natural GLP-1 hormone, which supports:

• Healthy insulin response when blood sugar is elevated.
• Reduced glucagon release to prevent glucose overproduction.
• Slower digestion, helping to reduce post-meal blood sugar spikes.
• Increased feelings of fullness, which may support appetite control.

These medications are used to manage type 2 diabetes or to support weight loss in eligible adults with obesity or weight-related conditions, under provider supervision.

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Where to Inject GLP-1 Medications

Subcutaneous injections are placed in the fatty layer just beneath the skin. Recommended sites include:

• Abdomen, two inches away from the navel.
• Thighs, front of the upper leg.
• Upper arms, outer upper arm (may require assistance).

To prevent irritation or lumps:

• Rotate sites weekly.
• Leave at least one inch of space between injection points in the same area.(Time)

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Step-by-Step: How to Inject Safely

Step 1: Prepare Supplies

• Wash hands thoroughly.
• Gather your pen or syringe, alcohol swab, and a sharps disposal container.
• Inspect medication to ensure it is clear, colorless, and free of particles.

Step 2: Choose and Clean Injection Site

• Select a recommended injection area.
• Clean the site with an alcohol swab and allow it to dry completely.

Step 3: Inject the Medication

If using a prefilled pen:

• Remove the cap and attach a new needle if needed.
• Dial to your prescribed dose.
• Pinch the skin and insert the needle at a 90-degree angle.
• Press and hold until the dose counter reaches zero, then count to six before removing.

If using a syringe and vial:

• Draw up the prescribed dose using a sterile syringe.
• Insert the needle into the pinched skin at a 90-degree angle.
• Inject slowly and steadily, then withdraw the needle.

Step 4: Dispose of Used Materials

• Place used pens or needles in a sharps container.
• Do not reuse needles or share devices with others.
• Follow local guidelines for sharps disposal.

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Storage Guidelines

Unopened Medication:

• Keep refrigerated between 36°F and 46°F.
• Do not freeze.
• Store away from direct light and never in refrigerator doors.

Opened Pens:

• Store at room temperature below 86°F.
• Most pens can be used for up to 56 days once opened. Check your specific product.
• Use an insulated travel case when traveling.

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Best Practices for Injection Success

• Take your injection on the same day each week.
• Rotate injection sites regularly.
• Eat smaller meals and avoid greasy foods to reduce digestive side effects.
• Stay hydrated and monitor how your body responds.
• Keep all follow-up appointments and labs recommended by your provider.

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Final Thoughts

Learning how to inject GLP-1 medications correctly is essential for safety, comfort, and treatment success. Over time, self-injection becomes easier and more routine for most individuals. Eden supports you every step of the way with access to licensed providers and personalized care.

GLP-1 medications are a powerful tool, but consistent use, healthy habits, and provider oversight are key to long-term progress.

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This guide is for educational purposes only and does not substitute for medical advice. Always follow the directions provided by your licensed healthcare provider. Compounded medications are not FDA approved and must be prescribed and monitored by a qualified clinician.