How to Inject GLP-1 Medications Safely: A Step-by-Step Guide

GLP-1 receptor agonists are prescription medications used to support blood sugar regulation and metabolic health in adults with type 2 diabetes or weight-related conditions. These therapies are commonly administered once weekly via subcutaneous injection.

Whether you have just started therapy or want a refresher on best practices, this guide outlines safe and effective injection techniques for GLP-1 medications.

Please note that this is not medical advice; please consult with your licensed healthcare provider for information specific to your health.

What Are GLP-1 Receptor Agonists

GLP-1 receptor agonists mimic the body’s natural GLP-1 hormone, which supports:

• Healthy insulin response when blood sugar is elevated.
• Reduced glucagon release to prevent glucose overproduction.
• Slower digestion, helping to reduce post-meal blood sugar spikes.
• Increased feelings of fullness, which may support appetite control.

These medications are used to manage type 2 diabetes or to support weight loss in eligible adults with obesity or weight-related conditions, under licensed healthcare provider supervision.

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Where to Inject GLP-1 Medications

Subcutaneous injections are placed in the fatty layer just beneath the skin. Recommended sites include:

• Abdomen, two inches away from the navel.
• Thighs, front of the upper leg.
• Upper arms, outer upper arm (may require assistance).

To prevent irritation or lumps:

• Rotate sites weekly.
• Leave at least one inch of space between injection points in the same area.

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Step-by-Step: How to Inject Safely

Step 1: Prepare Supplies

• Wash hands thoroughly.
• Gather your pen or syringe, alcohol swab, and a sharps disposal container.
• Inspect medication to ensure it is clear, colorless, and free of particles.

Step 2: Choose and Clean Injection Site

• Select a recommended injection area.
• Clean the site with an alcohol swab and allow it to dry completely.

Step 3: Inject the Medication

If using a prefilled pen:

• Remove the cap and attach a new needle if needed.
• Dial to your prescribed dose.
• Pinch the skin and insert the needle at a 90-degree angle.
• Press and hold until the dose counter reaches zero, then count to six before removing.

If using a syringe and vial:

• Draw up the prescribed dose using a sterile syringe.
• Insert the needle into the pinched skin at a 90-degree angle.
• Inject slowly and steadily, then withdraw the needle.

Step 4: Dispose of Used Materials

• Place used pens or needles in a sharps container.
• Do not reuse needles or share devices with others.
• Follow local guidelines for sharps disposal.

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Storage Guidelines

Unopened Medication:

• Keep refrigerated between 36°F and 46°F.
• Do not freeze.
• Store away from direct light and never in refrigerator doors.

Opened Pens:

• Store at room temperature below 86°F.
• Most pens can be used for up to 56 days once opened. Check your specific product.
• Use an insulated travel case when traveling.

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Best Practices for Injection Success

• Take your injection on the same day each week.
• Rotate injection sites regularly.
• Eat smaller meals and avoid greasy foods to reduce digestive side effects.
• Stay hydrated and monitor how your body responds.
• Keep all follow-up appointments and labs recommended by your provider.

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Final Thoughts

Learning how to inject GLP-1 medications correctly is essential for safety, comfort, and treatment success. Over time, self-injection becomes easier and more routine for most individuals. Eden supports you every step of the way with access to licensed providers and personalized care.

GLP-1 medications are a powerful tool, but consistent use, healthy habits, and provider oversight are key to long-term progress.

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This guide is for educational purposes only and does not substitute for medical advice. Always follow the directions provided by your licensed healthcare provider.