Why Am I Not Losing Weight on Semaglutide?

Why Am I Not Losing Weight on Semaglutide?

1. You're Early in the Process
   Weight loss often starts slowly. In STEP trials, participants saw a >5% BMI reduction only after 12–16 weeks, with maximum effects at weeks 52–68. Be patient with early phases ³.

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2. Your Dose May Still Be Low
   Semaglutide starts at 0.25 mg/week, titrated gradually. Suboptimal dose levels early in treatment may delay appetite suppression and fat loss. Always follow your provider’s titration plan for safety and efficacy ³.

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3. Missed or Inconsistent Dosing
   Semaglutide requires regular weekly use to maintain hormone balance. Missed doses can interrupt appetite suppression and insulin regulation ⁴.

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4. No Dietary Changes
   Semaglutide reduces hunger; not calories directly. If you're still consuming high-calorie foods, especially ultra-processed items, weight loss may plateau ⁵.
   Focus on:
   
   • Protein (chicken, fish, tofu)
   • Fiber (vegetables, legumes)
   • Whole grains and healthy fats

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5. Limited Physical Activity
   Though not mandatory, physical activity enhances outcomes. In STEP trials, semaglutide combined with behavioral support led to greater weight loss than medication alone ⁵.

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6. Medical Conditions or Medications
   Factors like:
   
   • Hypothyroidism
   • Polycystic ovary syndrome (PCOS)
   • Corticosteroid or antidepressant use
     can interfere with weight loss. Ask your provider about labs or adjustments ⁶.

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How to Maximize Results on Semaglutide

• Take medication on schedule
  
• Follow your provider’s dose titration plan
  
• Eat real, nutrient-dense foods
  
• Get 150+ minutes/week of activity
  
• Use apps or journals to track meals and progress
  
• Communicate with your provider regularly

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GLP-1 Treatments

Personalized doctor-led plans

As low as $196/mo*

Get started

*On a 12-month plan.

Important safety information

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Why Appetite Suppression Isn’t Enough Alone

Even with semaglutide’s help, weight loss may stall if meals are:

• Calorie-dense
  
• Low in protein
  
• Emotionally driven
  
  

Pair semaglutide with:

• Mindful eating
  
• Smaller portions
  
• Consistent hydration

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Common Barriers: Fatigue & Side Effects

In early weeks, calorie reduction may cause:

• Mild fatigue
  
• Dizziness
  
• GI symptoms like constipation or nausea
  
  

These typically subside with time. If they persist, a provider may adjust your dose or nutrition plan.

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How Eden Supports Your Journey

Eden connects patients with clinicians who:

• Customize plans based on your needs
  
• Provide follow-up care, symptom tracking, and support
  
• Help with cost transparency and lifestyle planning

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Final Thoughts

If you're wondering “Why am I not losing weight on semaglutide?” — consider timing, dose, consistency, and lifestyle. GLP-1 therapy is not a magic bullet, but a powerful tool best used with long-term habits and clinical oversight.

‍

GLP-1 Treatments

Personalized doctor-led plans

As low as $196/mo*

Get started

*On a 12-month plan.

Important safety information

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Disclaimer

This article is for educational purposes and does not replace medical advice. Semaglutide must be used under the supervision of a licensed healthcare provider. Eden offers access to clinically guided, personalized GLP-1 care plans.