What Does Progesterone Do? Why Might You Need It?

What Is Progesterone?

Progesterone is a naturally occurring hormone produced mainly in the ovaries after ovulation. It helps regulate the menstrual cycle and supports the early stages of pregnancy. Smaller amounts are also produced by the adrenal glands and, during pregnancy, the placenta.

In men, progesterone is present in much smaller quantities and supports other hormonal pathways.

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What Does Progesterone Do?

Regulates the Menstrual Cycle 

Progesterone helps prepare the uterine lining for a possible pregnancy and signals the body to shed the lining if pregnancy does not occur.

Supports Reproductive Health

During early pregnancy, progesterone plays a key role in helping to sustain the uterine lining.

May Interact with Other Systems

Some research suggests that progesterone may interact with receptors in the brain related to sleep, mood, and cognition. These findings are preliminary and not conclusive. Always speak to a licensed provider for personalized evaluation.

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Why Progesterone Levels May Change

Progesterone levels can fluctuate due to several common life stages or health-related conditions:

1. Perimenopause and Menopause

As women approach menopause, ovulation becomes less consistent, which may reduce progesterone production.

2. Chronic Stress

Chronic stress may impact hormone regulation, potentially influencing progesterone levels.

3. Ovulatory or Thyroid Disorders

Conditions such as polycystic ovary syndrome (PCOS) or certain thyroid conditions may lead to irregular ovulation, which can reduce progesterone production.

4. Postpartum and Breastfeeding

Progesterone naturally drops after childbirth, and levels may take time to return to baseline, especially while breastfeeding.

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When to Discuss Progesterone With a Provider

Only a licensed healthcare provider can diagnose hormonal imbalances. However, individuals experiencing the following symptoms may consider seeking an evaluation:

• Irregular or missed periods
• Sleep disruptions
• Mid-cycle fatigue
• Mood changes
• Night sweats or hot flashes
• Breast tenderness not associated with menstruation
• Decreased libido
• Skin changes or breakouts

Because these symptoms may overlap with other conditions, professional testing and evaluation are important.

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How Is Progesterone Tested?

Progesterone is typically measured with a blood test at specific points in the menstrual cycle. Providers may also assess other hormones such as estrogen or thyroid hormones for a more complete picture.

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What Happens If Progesterone Levels Are Low?

If a licensed provider determines that progesterone levels are lower than expected, they may recommend treatment options based on your specific needs and medical history. One option may include bioidentical hormone replacement therapy (BHRT).

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Forms of Bioidentical Progesterone

Bioidentical progesterone may be prescribed in several forms, including:

• Oral capsules
• Topical creams
• Vaginal suppositories
• Sublingual lozenges

Some formulations are available through traditional pharmacies, while others are prepared by licensed compounding pharmacies based on provider instructions. Eden connects patients with licensed healthcare providers who can determine the appropriate approach.

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Why Talk to a Provider First?

Hormone therapy is not a one-size-fits-all solution. A licensed provider can evaluate your full health history, symptoms, and lab results to determine whether progesterone therapy or another option may be appropriate for you.

Eden connects patients with independent, licensed providers who offer digital consultations and may coordinate lab testing. If a treatment is prescribed, medications are filled by independent, state-licensed pharmacies.

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Who Might Be a Candidate for Progesterone Therapy?

Progesterone therapy may be considered by licensed providers for individuals experiencing:

• Menopausal or perimenopausal symptoms
• Irregular ovulation
• Hormonal imbalance requiring estrogen-progesterone support
• Symptoms believed to be connected to low progesterone (as determined by lab testing)

Treatment decisions are always made by licensed providers based on each individual’s needs and lab data.

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Common Questions About Progesterone

Is Progesterone Safe?

When prescribed and monitored by a licensed provider, bioidentical progesterone is considered safe for many individuals. It is distinct from synthetic progestins and may have different effects. Always follow your provider’s instructions and share any side effects during treatment.

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Will It Help With Weight or Mood?

Progesterone is not FDA-approved for managing weight or mood. While some individuals report changes during treatment, there is no guarantee of therapeutic effect. Always consult a licensed provider for medical guidance.

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Can I Get This at a Regular Pharmacy?

Some forms of progesterone may be available through traditional pharmacies. Others may require compounding by a state-licensed pharmacy. Eden connects individuals with independent providers who evaluate symptoms and determine whether treatment is appropriate. If a prescription is issued, it is filled by a state-licensed pharmacy.

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How to Take the Next Step

If you're experiencing symptoms that could be related to hormone changes, a licensed provider can help evaluate your situation. Eden connects individuals with independent providers who evaluate symptoms and determine whether treatment is appropriate. All prescriptions are written at the sole discretion of the provider.

You don’t have to navigate hormone health alone. Eden can help connect you with a provider to explore your concerns and determine appropriate next steps.

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Conclusion

Progesterone is a key hormone involved in reproductive health and broader hormonal balance. While levels may change due to age or other factors, licensed providers can help assess whether treatment is appropriate. Eden offers a digital platform that helps connect you with licensed providers who can assess hormone-related concerns and determine whether treatment may be appropriate.

Start your evaluation today

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Disclaimer: Eden is not a medical provider or a pharmacy. Eden connects individuals with independent, licensed healthcare providers who independently evaluate each patient to determine whether a prescription treatment program is appropriate. All prescriptions are written at the sole discretion of the licensed provider. Medications are filled by independent, state-licensed pharmacies. Eden does not manufacture, own, or dispense any medications. No health claims are made unless supported by multiple peer-reviewed studies. Please consult a licensed healthcare provider before making any medical decisions.