Semaglutide Shots: What Patients Want to Know

Curious about semaglutide shots? Learn how they work, what to expect, and how Eden connects you with licensed providers for personalized care.

Key takeaways
  • Semaglutide shots are once-weekly injections prescribed for certain patients to support blood sugar regulation or metabolic health goals.
  • These injections mimic a natural hormone in your body that affects digestion, appetite, and insulin response.
  • A prescription is required from a licensed healthcare provider.
  • Semaglutide is only prescribed when clinically appropriate and dispensed through state-licensed U.S. pharmacies.
  • Eden connects you with independent licensed medical providers, but does not manufacture or ship medications.

This content is for informational purposes only and does not constitute medical advice. Medications like semaglutide are only prescribed when clinically appropriate and are dispensed through state-licensed pharmacies. Eden is not a pharmacy or healthcare provider.

If you're researching GLP-1 medications and have come across semaglutide shots, you’re not alone. These once-weekly injections have generated a lot of interest for their potential to support metabolic health goals. But what exactly are they, how do they work, and what should you know before starting?

This article answers common questions about semaglutide shots, from how they're administered to what to expect in terms of side effects, support, and results. We’ll also explain how Eden helps connect you with licensed healthcare providers who determine whether this treatment is appropriate for you.

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What Are Semaglutide Shots?

Semaglutide shots are injectable medications given once per week, typically using a small, easy-to-administer subcutaneous injection (under the skin). They belong to a class of medications called GLP-1 receptor agonists, which work by mimicking a naturally occurring hormone in your body.

There are FDA-approved versions of semaglutide on the market, such as Ozempic® (approved for type 2 diabetes) and Wegovy® (approved for long-term weight management in qualified patients). However, these medications are prescription-only and should only be used under the supervision of a licensed healthcare provider.

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How Do Semaglutide Injections Work?

Semaglutide activates GLP-1 receptors in the body, which are involved in several key processes related to metabolism:

  • Slows digestion, so you feel fuller longer
  • Supports insulin release, helping regulate blood sugar levels
  • Reduces appetite signals in the brain
  • Improves blood sugar stability by lowering the amount of sugar released by the liver

These combined effects may support metabolic health when used as part of a comprehensive plan that includes provider oversight, nutrition, movement, and other lifestyle strategies.

Who Might Be Prescribed Semaglutide Shots?

Semaglutide shots may be prescribed for people who meet specific clinical criteria, often related to blood sugar regulation or body weight. But it’s not for everyone.

A licensed healthcare provider will evaluate:

  • Your medical history and current health conditions
  • Your goals and prior treatment history
  • Lab results, including markers like A1C or fasting glucose
  • Any medications you’re currently taking
  • Risk factors or contraindications

Only if the provider determines that semaglutide is clinically appropriate for your situation will a prescription be written.

What to Expect When Starting Semaglutide Shots

If prescribed semaglutide, your provider will likely start you on a low dose and increase it gradually over several weeks. This process, called titration, is designed to help your body adjust and reduce the chance of side effects.

Common side effects may include:

  • Mild nausea
  • Digestive changes (such as constipation or bloating)
  • Headache or fatigue
  • Appetite changes

Most people find that side effects improve over time, especially when following the provider’s guidance on dosing and nutrition.

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How Are Semaglutide Shots Administered?

Semaglutide is injected subcutaneously, which means just under the skin, usually in the stomach area, thigh, or upper arm. The needle is small, and most patients report that the injection is quick and relatively painless.

You’ll receive instructions on:

  • How to self-administer your weekly injection
  • Where and how to rotate injection sites
  • How to store and handle the medication
  • What to do if you miss a dose

If you ever feel unsure, your provider or pharmacist can help walk you through the process.

Where Do the Injections Come From?

Once a licensed healthcare provider writes your prescription, it’s sent to a state-licensed U.S. pharmacy, where your medication is prepared and shipped directly to your door.

Eden works only with fully licensed pharmacies that comply with all state and federal regulations. Your medication is never shipped from unverified or international sources, and you’ll receive tracking information and instructions along with your shipment.

Important: Eden does not produce, sell, or ship medication. We connect individuals with independent licensed healthcare providers who, if clinically appropriate, prescribe treatment that a licensed pharmacy fills.

Do I Need to Make Lifestyle Changes Too?

Semaglutide shots are not a shortcut or magic fix; they’re part of a broader approach to health. While the medication may support appetite regulation and blood sugar stability, lasting results often depend on other factors, including:

  • What and how you eat
  • How you manage stress
  • Your sleep and movement habits
  • Support from healthcare providers

That’s why Eden’s platform emphasizes not just prescription access, but continued oversight from providers who understand how to tailor a plan to your needs.

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Is This the Same as Ozempic® or Wegovy®?

Ozempic® and Wegovy® are both brand-name versions of semaglutide, but they are FDA-approved for different uses:

  • Ozempic® is approved for type 2 diabetes
  • Wegovy® is approved for long-term weight management in certain individuals

Your provider will determine which version, if any, is appropriate based on your health profile and clinical need. Any semaglutide shot must be prescribed and monitored by a licensed healthcare provider.

Conclusion

Semaglutide shots may be a helpful tool for supporting metabolic health, but they’re not a one-size-fits-all solution. A safe, effective treatment plan starts with a conversation with a licensed provider who understands your unique needs.

At Eden, we make it easier to access that care by connecting you with independent licensed healthcare providers who can evaluate whether semaglutide is appropriate, and if so, guide you every step of the way.

Ready to learn if semaglutide shots might be part of your care plan?

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Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.

Eden is not a medical provider or a pharmacy. Eden connects individuals with independent licensed healthcare providers who independently evaluate each patient to determine whether a prescription treatment program is appropriate. All prescriptions are written at the sole discretion of the licensed provider. Medications are filled by independent, state-licensed pharmacies. Eden does not manufacture, own, or dispense any medications. Please consult a licensed healthcare provider before making any medical decisions.

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References

Ghusn, W., & Hurtado, M. D. (2024). Glucagon-like Receptor-1 agonists for obesity: Weight loss outcomes, tolerability, side effects, and risks. Obesity Pillars, 12, 100127. https://doi.org/10.1016/j.obpill.2024.100127

Research, C. F. D. E. A. (2025, July 29). FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss. U.S. Food And Drug Administration. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss

Research, C. F. D. E. A. (2022, October 24). How Drugs are Developed and Approved. U.S. Food And Drug Administration. https://www.fda.gov/drugs/development-approval-process-drugs/how-drugs-are-developed-and-approved

Wilding, J. P., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T., Wadden, T. A., Wharton, S., Yokote, K., Zeuthen, N., & Kushner, R. F. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989–1002. https://doi.org/10.1056/nejmoa2032183