Semaglutide for Weight Loss: What to Know First

How Does Semaglutide Work in the Body?

Semaglutide belongs to a class of medications known as GLP-1 receptor agonists. These drugs mimic the effects of glucagon-like peptide-1, a naturally occurring hormone involved in appetite regulation, insulin release, and blood sugar control.

In people with elevated BMI and related conditions, semaglutide may support:

• Reduced hunger between meals
  
• Lower appetite for calorie-dense foods
  
• A longer feeling of fullness after eating
  
  

A 2022 clinical trial evaluating 2.4 mg of semaglutide found that participants reported reduced appetite and lower energy intake, factors that may contribute to weight loss when paired with lifestyle changes.

The GLP-1 formulation used in this study is the same as the one later approved and marketed under the brand name Wegovy®.

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Is Semaglutide Approved for Weight Loss?

Yes, but only specific formulations. Semaglutide 2.4 mg, marketed under the name Wegovy®, is FDA-approved for chronic weight management in adults with:

• A BMI of 30 or higher (classified as obese), or
  
• A BMI of 27 or higher (classified as overweight) with at least one weight-related condition, such as high blood pressure or elevated cholesterol.
  
  

It is not approved as a general-use weight loss drug for cosmetic purposes or for individuals without qualifying medical criteria.

Eden helps individuals connect with independent, licensed healthcare providers who evaluate these factors and determine whether semaglutide is medically appropriate. Eligibility is not guaranteed.

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What Do Clinical Studies Say About Weight Loss?

Several clinical trials, particularly the STEP series of studies, have demonstrated that semaglutide 2.4 mg, when paired with diet and physical activity, may lead to weight loss in eligible adults.

One pivotal study published in the New England Journal of Medicine found:

• Participants receiving semaglutide 2.4 mg lost an average of 14.9% of their body weight over 68 weeks.
  
• Those using a placebo lost just 2.4%.
  
• Nearly 70% of participants on semaglutide lost at least 10% of their body weight.
  
  

These results occurred alongside healthy lifestyle changes and under clinical supervision.

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Who Might Be Eligible for Semaglutide?

Eligibility is determined by a licensed healthcare provider and generally depends on:

• Body Mass Index (BMI)
  
• Existing medical conditions (e.g., high blood pressure, type 2 diabetes, high cholesterol)
  
• Current medications
  
• Overall medical history
  
  

Eden enables you to discuss these factors in detail with a licensed provider, who will determine whether semaglutide is a safe and appropriate option for you.

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What Are the Potential Side Effects?

As with any prescription medication, semaglutide may cause side effects. Based on clinical trial data*, the most common include:

• Nausea
  
• Vomiting
  
• Diarrhea or constipation
  
• Abdominal discomfort
  
• Fatigue
  
  

Generally, side effects occur early in treatment and tend to subside as the body adjusts to the medication. In rare cases, more serious events like pancreatitis, gallbladder issues, or allergic reactions have been reported.

You should always discuss these risks with a licensed provider in advance. They can recommend a gradual dose-escalation strategy to help minimize discomfort.

*The study included semaglutide (branded as Ozempic® and Wegovy®), liraglutide (Saxenda®), exenatide (Byetta® and Bydureon®), dulaglutide (Trulicity®), and albiglutide (formerly Tanzeum®). Side effects listed were observed across multiple GLP-1 receptor agonists, including semaglutide (Ozempic®, Wegovy®), liraglutide (Saxenda®), and others in the class. Individual experiences may vary based on formulation and dosage.

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What to Ask Before Starting Semaglutide

Before beginning treatment, consider asking a licensed provider the following:

1. What’s my BMI, and does it meet eligibility criteria?
   
2. What lifestyle changes should I be making alongside this treatment?
   
3. How long is the treatment typically recommended?
   
4. What side effects should I expect and how can I manage them?
   
5. Are there any interactions with my current medications?
   
   

These questions can help guide a more informed and personalized approach to care.

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Eden's Role in the Process

Eden is not a pharmacy or medical provider. Instead, Eden is a digital health platform that helps individuals connect with independent, licensed healthcare providers for evaluation and access to treatments, including semaglutide when clinically appropriate.

Medications, if prescribed, are dispensed through state-licensed compounding pharmacies. Eden does not manufacture or create any medications.

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Conclusion

Semaglutide has emerged as a powerful tool in supporting metabolic health and weight management, but it’s not a one-size-fits-all solution. It’s important to understand how it works, who it’s approved for, and what to expect along the way.

By working with a licensed provider through Eden, you can make well-informed decisions about your health and determine if semaglutide is the right next step in your journey.

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