Semaglutide and Diarrhea: What to Know and How to Manage Digestive Side Effects

Why Semaglutide May Lead to Diarrhea

Semaglutide is a GLP-1 receptor agonist that may slow gastric emptying and influence appetite and gastrointestinal hormone activity. These mechanisms may contribute to digestive changes in some individuals, including nausea, bloating, or diarrhea.

Potential contributors to digestive symptoms may include:

• Increased gut motility during early use
• Temporary changes in water absorption
• Adjustments in diet made during treatment
• Individual sensitivity to GLP-1 receptor activity

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How Common Is Diarrhea with Semaglutide?

A 2024 meta-analysis of clinical studies found that approximately 8–10% of individuals reported diarrhea while taking semaglutide, particularly at higher doses. These symptoms were generally mild to moderate and were more frequently observed during the dose titration phase.

Does It Go Away on Its Own?

In many cases, diarrhea may improve within the first few weeks of treatment. Duration may depend on:

• How quickly the dose is escalated
• Individual digestive health and hydration status
• Dietary patterns

If symptoms persist for more than 1–2 weeks or interfere with daily life, it is important to speak with a licensed healthcare provider.

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Tips for Managing Diarrhea While on Semaglutide

Stay Hydrated

Staying well-hydrated may help support digestive health and reduce symptom severity. Individuals experiencing fluid loss should aim to replenish electrolytes as needed.

Adjust Your Diet

Some dietary modifications may help alleviate symptoms. Consider limiting the following, which may worsen digestive symptoms for some individuals:

• Greasy or fried foods
• High-fat dairy products (such as whole milk, cheese, or cream-based sauces)
• Alcoholic beverages and caffeinated drinks
• Sugar-sweetened beverages (including soda and sweetened juices)

Incorporate foods that are gentle on digestion, such as:

• Soluble fiber (e.g., oats, bananas)
• Cooked or steamed vegetables
• Lean proteins like chicken, tofu, or fish
• Smaller, more frequent meals

Increase Fiber Slowly

Gradually increase fiber intake to avoid worsening symptoms. Sudden increases may irritate the digestive tract.

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Consider Over-the-Counter Options (With Provider Approval)

In some cases, medications like loperamide may be appropriate, but they should only be used under the supervision of a licensed healthcare provider.

Consult a Licensed Provider

If symptoms are persistent or worsen, a licensed healthcare provider can evaluate and, if needed, adjust the treatment plan or investigate other causes.

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Eden’s Role in GLP-1-Based Treatment

Eden is a digital health platform that connects individuals to licensed healthcare providers who may prescribe GLP-1 medications when appropriate. Providers on the Eden platform may support patients with:

• Personalized dose escalation plans
• Guidance on managing gastrointestinal symptoms
• Ongoing virtual follow-up care

Medications are prescribed by licensed healthcare providers and filled by state-licensed compounding pharmacies.

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Final Thoughts

Some individuals may experience digestive symptoms such as diarrhea during semaglutide treatment, especially in the early stages. These effects are often manageable through hydration, dietary adjustments, and support from a licensed healthcare provider. Individuals are encouraged to seek medical guidance to optimize their treatment experience.

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