Semaglutide and Pregnancy: Safety Considerations for Fertility, Conception, and Breastfeeding

How Semaglutide May Influence Fertility Goals

Semaglutide is not approved as a fertility treatment. However, in individuals with overweight or obesity, it may improve insulin sensitivity and support weight loss, helping address conditions like PCOS. These changes may support ovulation and hormonal balance. 

While early evidence suggests potential fertility benefits, semaglutide should not be taken during an active fertility cycle or pregnancy. Clinical decisions must be licensed medical provider-guided.

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Is Semaglutide Safe During Pregnancy?

Semaglutide is not approved for use during pregnancy. Preclinical data show risks such as:

• Miscarriage
  
• Fetal malformations
  
• Reduced birth weight
  
  

Due to its long half-life, patients are advised to discontinue semaglutide at least two months before attempting conception.

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Can You Take Semaglutide While Breastfeeding?

There is limited human data on semaglutide and lactation. One study found the drug was not detected in breast milk samples, suggesting a low risk of infant exposure.

However, due to the lack of long-term safety data, alternatives like metformin or insulin may be recommended for managing metabolic conditions while breastfeeding.

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Pregnancy Planning and Semaglutide: Safety Guidelines 

1. Discontinue Early
   Stop semaglutide 8 weeks before conception to allow for clearance.
   
   
2. Talk to Your Provider
   Discuss family planning timelines to align treatment strategies.
   
   
3. Monitor Side Effects
   Be aware of potential complications like thyroid tumors, gallstones, or pancreatitis (Frontiers in Endocrinology).
   
   
4. Supportive Lifestyle
   Prioritize nutrition, physical activity, and avoid alcohol and tobacco.

Individuals who are pregnant, planning to become pregnant, or breastfeeding should consult with a licensed healthcare professional before starting or continuing treatment with semaglutide. A medical provider can help evaluate the risks and benefits of treatment and provide guidance tailored to your reproductive health goals.

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Choosing the Right Form of Semaglutide

Semaglutide comes in:

• GLP-1 injection form: Ozempic®, Wegovy®
  
• Oral form: Rybelsus®
  
  

Consult your licensed healthcare provider to determine the most appropriate format, particularly during reproductive planning.

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Final Thoughts

Semaglutide may be effective for metabolic support, but should be used with caution around pregnancy and breastfeeding. Its use must be guided by a licensed medical provider, and patients should discontinue it before conception efforts.

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Disclaimer

The information provided in this article is for general educational purposes only and is not intended as medical advice. Semaglutide is not approved for use during pregnancy, and its safety has not been established for individuals who are pregnant, planning to become pregnant, or breastfeeding. Treatment decisions should always be made in consultation with a licensed healthcare provider who can evaluate the potential risks and benefits based on your individual health needs. Eden does not practice medicine or prescribe treatments; we connect patients with licensed medical professionals who provide personalized care.

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