Semaglutide and Pancreatitis: What You Need to Know

Is There a Link Between Semaglutide and Pancreatitis?

GLP-1 receptor agonists like semaglutide mimic a natural hormone that supports blood sugar regulation and appetite signaling. While effective for approved indications, the prescribing information for semaglutide includes a warning about acute pancreatitis based on postmarketing reports. Although a definitive causal relationship has not been confirmed, individuals using these medications should be aware of the potential risk. Discussions with a licensed healthcare provider can help determine whether this medication is appropriate, especially for those with known risk factors. 

Symptoms of Pancreatitis to Watch For

If you are using semaglutide, monitor for the following symptoms that may indicate pancreatitis:

• Persistent or severe upper abdominal pain
  
• Nausea or vomiting
  
• Pain that radiates to the back
  
• Fever or increased heart rate
  
  

If these symptoms develop and persist, seek immediate medical attention from a licensed healthcare provider.

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Who May Be at Higher Risk?

Certain individuals may face a greater risk of pancreatitis. Risk factors may include:

• A personal or family history of pancreatitis
  
• Heavy or chronic alcohol use
  
• Gallbladder disease or elevated triglycerides
  
• Previous pancreatic conditions
  
  

Before starting semaglutide or any GLP-1 receptor agonist, consult with a licensed healthcare provider and share your full medical history.

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Common Side Effects of Semaglutide

While the risk of pancreatitis is rare, other side effects may be more common, particularly when first starting the medication. These may include:

• Nausea and vomiting
  
• Diarrhea or constipation
  
• Headache or fatigue
  
• Injection site reactions
  
• Low blood sugar (especially when combined with certain other medications)

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Nausea and Vomiting

Eating smaller meals and avoiding rich or high-fat foods may reduce nausea. These symptoms may decrease over time.

Diarrhea or Constipation

Adjusting fiber intake and staying hydrated may help manage changes in bowel movements.

Injection Site Reactions

Redness or swelling at the injection site is usually temporary. Rotating injection areas may reduce irritation.

Blood Sugar Levels

Low blood sugar may occur, particularly when semaglutide is combined with medications like insulin. Follow your provider’s directions closely.

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Can Semaglutide Be Used Safely?

For many people, semaglutide can be used safely under the guidance of a licensed healthcare provider. Ongoing monitoring, gradual dose adjustment, and communication about side effects all contribute to safer use. Eden connects patients with licensed healthcare providers on the Eden platform who can evaluate their health goals and determine whether GLP-1 medications may be appropriate. Eden does not manufacture, compound, or dispense medications. Eden is not a pharmacy or a healthcare provider.

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Disclaimer

This content is for informational purposes only and is not a substitute for professional medical advice. Always consult a licensed healthcare provider before starting or stopping any medication.

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