GLP-1 vs. SGLT2 for Metabolic Health

What Are GLP-1 and SGLT2 Medications?

GLP-1 receptor agonists and SGLT2 inhibitors are both used to help manage type 2 diabetes. They are often considered as part of a broader metabolic care approach, depending on a patient's health profile. While these medications are effective in supporting blood sugar regulation, their methods of action and additional considerations vary significantly.

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How They Work in the Body

GLP-1 Receptor Agonists

GLP-1 receptor agonists, such as semaglutide or liraglutide, mimic a naturally occurring hormone called glucagon-like peptide-1. This hormone plays a role in:

• Stimulating insulin release after meals
  
• Slowing down digestion
  
• Supporting feelings of fullness
  
  

These medications are typically administered via injection or oral tablets, depending on the formulation.

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SGLT2 Inhibitors

SGLT2 inhibitors, such as Jardiance® or Farxiga®, work by targeting a protein in the kidneys that normally reabsorbs glucose. By inhibiting this protein, more glucose is removed from the body through urine. These medications are available in oral tablet form.

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Key Differences Between GLP-1 and SGLT2 Medications

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Which Option May Be Right for You?

Only a licensed healthcare provider can determine whether a GLP-1 or SGLT2 medication may be appropriate. Your provider will evaluate:

• Your personal health history
  
• Blood sugar levels and A1C trends
  
• Weight-related goals
  
• Cardiovascular or kidney-related conditions
  
• Risk of side effects and interactions with other medications
  
  

For individuals seeking support with metabolic health, GLP-1 medications may be considered, especially when lifestyle changes alone haven’t delivered desired outcomes. Some GLP-1 medications are FDA-approved for long-term weight management.

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Can GLP-1 and SGLT2 Be Used Together?

In certain clinical scenarios, licensed providers may consider using both a GLP-1 and an SGLT2 inhibitor for patients with complex metabolic needs. Published studies suggest that combining both medications may provide added support for blood sugar management and risk reduction in eligible patients.

However, combination therapy decisions must be guided by a licensed provider and are based on a thorough review of your medical history, current medications, and lab results.

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How Eden Can Help

Eden is a digital health platform that connects individuals with licensed healthcare providers who may prescribe GLP-1 medications when clinically appropriate.

Our process is private, personalized, and designed to help you make informed decisions about your care. If you're interested in exploring GLP-1 treatment options, a licensed provider on the Eden platform can review your health history and determine if a treatment program is right for you.

Please note: Eden does not currently facilitate access to SGLT2 inhibitors.

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Conclusion

GLP-1 and SGLT2 medications are both FDA-approved options for managing type 2 diabetes. GLP-1 medications work by mimicking natural hormones involved in insulin and appetite regulation, while SGLT2 inhibitors help lower blood sugar by promoting glucose loss through the kidneys.

Some GLP-1 medications are also approved for weight management in eligible patients, and licensed providers on the Eden platform may prescribe them as part of a customized care plan.

If you’re considering medical options to support your metabolic health, speaking with a licensed provider can help you understand your options.

Disclaimer: Eden is not a medical provider or a pharmacy. Eden connects individuals with independent licensed healthcare providers who independently evaluate each patient to determine whether a prescription treatment program is appropriate. All prescriptions are written at the sole discretion of the licensed provider. Medications are filled by independent, state-licensed pharmacies. Eden does not manufacture, own, or dispense any medications. No health claims are made unless supported by multiple peer-reviewed studies. Please consult a licensed healthcare provider before making any medical decisions.